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The rapid and coordinated repression of histones and M/G1-specific transcripts cannot be explained by cell cycle arrest, and suggested that there are additional signaling pathways that directly repress these genes in cells under genotoxic stress.
Assessment of the lists according to those pathways that directly correlate with PD pathogenesis (Table S5) revealed that in all pathways gene groups were dysregulated in both mPD and fPD (Figure 4).
Liver regeneration after partial hepatectomy (PH) is a process of compensatory hyperplasia which involves all cell types within the remaining liver lobes and depends on the multitude of interrelated regulatory pathways that directly or indirectly control successful restoration of hepatic mass [1] [3].
Therefore, we sought to define specific signalling pathways that directly alter cellular transcription.
And the pathways in gray lines are the pathways that directly linked with diabetes r by the marked genes.
Alternatively, NRP1 may modulate signal transduction pathways that directly regulate tip cell behavior, such as cytoskeletal remodeling and filopodia extension.
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Recently, a novel pathway that directly releases active cytokinins from their nucleotides was identified [13].
We hypothesized that genes in the mTOR pathway and genes of the p53 pathway that directly relate to mTOR may be centrally implicated in prostate carcinogenesis, and that polymorphic alleles in these genes could modify their expression or activity, thus conferring altered prostate cancer susceptibility.
Taken together, our results revealed an autophagic pathway that directly imports RNA into lysosomes for degradation.
The identity of nuclear targets of the MAPK signaling pathway that directly activate Cbfb expression remains unclear.
How TDAG51 expression might suppress ERK signaling is not known, but appears to represent a negative feedback pathway that directly or indirectly limits ERK activation.
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