Sentence examples for pathways that actively from inspiring English sources

Although we are rapidly gaining a more complete understanding of the genes required for kidney function, the molecular pathways that actively maintain organ homeostasis are only beginning to emerge.

Metformin's ability to prevent reproductive aging while increasing lifespan, if both occurring through AMPK activation-mTOR/S6K1 deactivation, appears to largely agree with a gerosuppressive functioning of metformin (i.e. gerosuppressants are pharmacological agents that inhibit intracellular signaling pathways that actively drive cellular aging and thus suppress the aging process [ 151, 152]).

These enzymes in turn are functionally linked to pathways that can actively repress death by modulating the expression and/or activity of various apoptosis repressors, including members of the bcl-2 family [ 13].

The JAK family of tyrosine kinases and STAT are important components of diverse signal transduction pathways that are actively involved in cellular survival, proliferation, differentiation and apoptosis.

The predicted target genes were classified according to KEGG functional annotations to identify pathways that were actively regulated by miRNA in M. amblycephala (Additional file 9: Table S6).

DNA damage and other stimuli act through both p53-dependent and -independent pathways that are actively being characterized (for a summary see [ 20]).

The predicted target genes were further classified to identify pathways that were actively regulated by miRNAs in adipose tissues according to KEGG functional annotations (Tables  2 and 3).

To test whether DINA was able to identify tissue-specific pathways, i.e. pathways that are actively regulated only in specific tissues, we used the full manually curated list of 186 KEGG pathways from MsigDb (Kanehisa et al., 2002; Liberzon et al., 2011) including signaling, metabolic and regulatory pathways.

The mammalian retina does not have the innate ability to regenerate damaged retina, but research is actively exploring pathways that promote endogenous regeneration.

The second pathway, demonstrated in this study, is a novel cell contact induced and JAK2-dependent pathway that generates tolerogenic DCs with a distinct altered-mature phenotype that actively suppress T-cell activation.

However, accumulating evidence shows that some forms of necrosis actively involve defined signaling pathways that contribute to the cellular demise, as is the case for apoptosis.