(iv) Endopeptidase inhibitors are often part of an inducible, jasmonic acid associated defence pathway that accumulates upon wounding, pathogen, or herbivore damage in leaves [ 26].
We propose at least three factors as important for determining the sites of relapse in MS patients: (1) the existence of excess MHC class II+CD11b+ cells at a particular site, (2) activation of a sympathetic pathway that accumulates MHC class II+CD11b+ cells in certain blood vessels, and (3) the presence of organ-specific autoreactive CD4+ T cells in the periphery.
Our understanding of tocochromanol function(s) during the plant life cycle has been advanced by the isolation and study of pathway mutants that accumulate specific intermediates or completely eliminate tocochromanols from the organism.
Having determined the composition of on-pathway intermediates that accumulate upon deletion of RimP, fractions from the 30S peak of a Δ rimP strain sucrose gradient were additionally analyzed by negative stain EM as described above for WT to determine the distribution of conformations present across the gradient.
We suggest that this is accomplished through the transcriptional control of metabolic pathways that produce osmoprotectant metabolites that accumulate in the roots.
Mangieri, L. R. et al. ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.
Moreover, the pathway signature predictions are also reflective of additional mutations that accumulate in the samples.
In addition, minor metabolic pathways that usually lie dormant may be activated when a substrate accumulates, possibly forming atypical, potentially toxic, products.
Among integrin subunits, α4 exhibits unique properties in that it predominantly accumulates at the leading edge of migrating cells; however, the pathways that link the actin-regulatory machinery to α4 at the leading edge have remained elusive.
A completely separate pathway involves a large amount of calcium accumulating in cells, which may impair oxidative metabolism and begin further biochemical pathways that result in cell death.
