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The simulations of degradation pathways show a common pathway in the stepwise degradation of the side chain in ortho position to the hydroxyl group.
Ent-kaurene is a precursor for gibberellin biosynthesis, whose pathways show a similar pattern of variation (Figure 5).
Two pathways show a highly significant association within Chin et al. alone and 4 pathways show significance across multiple data expression datasets.
In that study, embryo development, pattern specification, cell cycle, apoptosis, NOTCH, NODAL and other pathways were found to be transcriptionally conserved as the genes of these pathways show a significant cross-species correlation on the transcriptional response to ESC differentiation.
Both of these pathways show a negative regulation in the ERK2 morphants, as shown by the GenMAPP analysis (Fig. 6, 7, 8, 9).
On the other hand, many natural biosynthetic pathways show a surprising level of built-in modularity at many levels, which can be exploited by the engineering approaches of synthetic biology [ 11,12].
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Akt/PIP3 pathways show an important role in the development and progression of tumour.
In general, cancer-related gene sets, such as MYC and E2F targets and G2M, showed a "normal-like" tendency in NAT; normal cellular differentiation pathways, such as adipogenesis and myogenesis, showed a "gradient" tendency; and inflammatory-related pathways showed a "tumor-like" tendency (Fig. 4b).
Interestingly, aggregates from both pathways showed a β-sheet conformation but differed in their ThT binding capability and morphology.
A further two pathways showed a trend toward significance (i.e. IGF-1 [p = 0.051] and PTEN [p = 0.055]; see Figure 3A).
Most of genes in the pathways showed a co-expression pattern, some of which were members of conserved co-expression clusters (Tables 1 and S1, Figure S2).
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