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The major bioprocesses and pathways shared by Patterns 46 and 47 include "circadian clock" and "metabolism of lipids and lipoproteins" (Fig. 5c).
The analyses showed that the discovered genes were highly enriched in gene ontology terms and KEGG pathways shared by known proliferative diabetic retinopathy related genes.
Because essential components of a process tend to be conserved over the course of evolution, identifying regenerative pathways shared by many species would be a powerful method to uncover as yet unknown regulators of regeneration.
The KEGG pathway analyses were performed on the SDE genes in each cell line, which identified the common pathways shared by the two cell lines and found that the most enriched pathways were different between the two cell lines (Sup Figs 2, 3).
Also, 8 of the 10 pathways shared by the two patients are present in either of the two unaffected members of the two twin pairs.
Previous studies detected a neurochemical pathways shared by migraine, psychopathology and emotional regulation, that could play a role in this association.
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The toxicological pathway shared by many halobenzenes is suggested by Sakuratani et al. [15] and Greim [35].
This suggests that the major cold-responsive genetic pathway shared by C418 and K354 is possibly a DREB1-related pathway.
In contrast, rVSMC binding to fibronectin may activate a signaling pathway shared by PDGF that ultimately converges in MAPK activation.
The recovery process however, is mediated by an increased intracellular cAMP level and negative feedback inhibition, a pathway shared by 'endothelial stabilisers', such as prostaglandin (PGI2).
USGSA can also help to identify a significant pathway shared by different traits which however may be activated through different mechanisms.
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