Exact(34)
We used this approach to reveal cellular pathways responding to the toxicity of alpha-synuclein, a protein implicated in several neurodegenerative disorders including Parkinson's disease.
However, the rationale underlying combinatorial therapy is often not well established due to lack of understandings of the specific pathways responding to the drugs, and their temporal dynamics following each treatment.
The purpose of this study was to identify downstream targets and pathways responding to the over-expression of paternal allele-specific and maternal allele-specific genes due to the callipyge mutation.
In this work it has been shown that VRK2 downregulates the response to IL-1β mediated via TAK1, thus the response to IL-1β may be relatively enhanced by altering the balance between the pathways responding to multiple simultaneous stimuli the cell is exposed in its tissue niche.
SRF6 is potentially acting in pathways responding to fungal infections.
Through this work, we have identified key genes and pathways responding to dichlorvos toxicity.
Similar(26)
MAPK signaling pathways respond to various extracellular stimuli and function to regulate cell proliferation, differentiation, regeneration, response to stress, and apoptosis8,9.
Connecting insights across these approaches presents significant challenges primarily because we lack information about how signalling pathways respond to dietary complexity.
Moreover, we discuss novel approaches that are allowing us to explore how pathways respond to changes in inputs and even predict the fate of a cell based upon its signalling history and state.
A second set of OxyR-independent genes, respond to general ROS, revealing that multiple pathways respond to oxidative stress [19].
It can reveal how fast the biological pathways respond to perturbation of environments and how accurately the pathways can finally achieve the desired steady-state values.
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