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Azathioprine, a relatively toxic drug, exerts its pharmacological action by inhibiting several enzymatic pathways required for the synthesis of DNA.
RANKL RANK signaling activates a variety of downstream signaling pathways required for osteoclast development.
Sullivan KG, Levin M. Neurotransmitter signaling pathways required for normal development in Xenopus laevis embryos: a pharmacological survey screen.
New functional profiling methods24 identified pathways required for microbial colonization of the human body, differentiating those enriched for the human habitat from those universal to microbial life.
The role of the TCR and the downstream signaling pathways required for this suppressive function of Tregs are not fully understood.
By inhibiting several enzymatic pathways required for the synthesis of deoxyribonucleic acid (DNA), azathioprine decreases the number of lymphocytes (a type of white blood cell) that can migrate to inflammatory sites.
A holistic model of mathematical oncology has been provided to identify key signaling pathways required for the phenotypic reprogramming of cancer through an epigenetic landscape.
This approach identified three cellular pathways required for DENV replication: autophagy, actin polymerization, and fatty acid biosynthesis.
Although the 3D architecture of these structures has recently been described, little is known about the cellular pathways required for their formation and expansion.
As a researcher at Columbia, Rothman investigated the signaling pathways required for allergic immune responses and cancer, a focus he has maintained while at Iowa.
As a critical tumor suppressor, p53 is inactivated in human cancer cells by somatic gene mutation or disruption of pathways required for its activation.
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