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Cofactor biosynthetic pathways represent a rich source of potential antibiotic targets.
From this it is clear that the integration of these topologically linked pathways represent a true series of biochemical events linking the binding of the Wnt ligand, through activation of Daam1 to the actin polymerization machinery.
In conclusion, we showed that SHH pathway could be involved in the self-renewal, proliferation, drug resistance and tumorigenic of tumorsphere cells and suggest that strategies aimed at inhibiting SHH pathways represent a rationale therapeutic approach to target gastric CSCs.
To investigate whether the depletion of PKCι and p38MAPK pathways represent a general mechanism of expanded polyglutamine toxicity, we transfected control or PKCι depleted cells with an expression construct encoding the full length ataxin-1 gene product with an expanded polyglutamine tract of 83Q (hereafter referred to as Atx-83).
Canonical pathways represent a set of about 500 signalling and metabolic maps in the MetaCore suit.
Inherent defects in DNA repair pathways represent a common feature characterising susceptibility to PARP inhibitors [ 22, 23].
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These pathways represent an important shift in conservation strategy.
Endogenous ROS-scavenging pathways represent an antioxidant defense system, including both small molecules (tocopherols, vitamin C, glutathione, etc).
The emergence and evolution of metabolic pathways represented a crucial step in molecular and cellular evolution.
Targeted engineering of lipogenic pathways represents a promising strategy to enhance the efficacy of microalgal oil production.
Understanding the complex interactions that occur between heterologous and native biochemical pathways represents a major challenge in metabolic engineering and synthetic biology.
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