Sentence examples for pathways remain functional from inspiring English sources

Moreover, the fact that ubiquitinated EGFR is in most cases not targeted to the proteasome may indicate that signaling pathways remain functional despite the ubiquitination of their proteins, but this remains to be investigated.

We bioengineered sphincteric rings from human IAS smooth muscle cells (SMC) and investigated their response to cholinergic stimulation as well as investigated whether protein kinase C (PKC) and Rho kinase signaling pathways remain functional.

Considerable evidence has demonstrated that these pathways remain functional in a limited number of cells within the adult and that dysregulation of these pathways contributes to the formation and persistence of tumors [2], [3].

Upon treatment with E2, SDF-1 expression went up over two-fold, again suggesting that ER dependent signaling pathways remained functional after long term exposure to the anti-estrogen.

Samples were collected under conditions demonstrated previously to induce thymic atrophy and immunosuppression (reviewed by Dean et al. 1985), when transcriptional analysis might show which pathways remained functional and which were compromised.

To confirm that the p53 pathway remained functional in FHL2−/− cell lines, we assessed the expression of p53 target genes at the whole-genome level by comparing gene expression profiles of three FHL2−/− cell lines with those of three immortalized wt MEF clones using Affymetrix Mouse Genome 430 2.0 microarray[5].

Systematic deletion of FG-repeat regions in yeast nucleoporins revealed, however, that yeast NPCs suffer from only slight changes in distinct nuclear transport pathways, but otherwise remain functional despite having removed up to 50% of their FG-repeats (Strawn et al. 2004).

Interestingly, in MM cells with loss of Arf, the p53 pathway appeared to remain functional based on response to DNA damage (Fig. 3C).

Interestingly, in MM cells with loss of Arf, the p53 pathway appeared to remain functional intact based on their response to DNA damage with etoposide (100 µM) or UV irradiation (80 J/m2) (Fig. 3C).

Our results are similar to the finding that the enzyme catalyzing reactions downstream of the defect in the melanin synthesis pathway in cave adapted insects remain functional because they also play an important role in the innate immune response and in wound healing in arthropods [ 50- 52].

We also show that two pathways that can induce PGC-1α remain functional and can be stimulated in order to stimulate a down-stream response.