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Targeting proliferative and survival pathways provides a rationale for drug design and development for hormone refractory prostate cancer.
Unlike graph-based paths which may only include the main compounds and reactions in a pathway, elementary flux modes and extreme pathways provides a more complete summary of the requisite intermediate compounds and enzymes while conforming to steady-state constraints.
Identifying and characterizing these core pathways provides a foundation for therapeutic development.
Given the importance of oncogene activation in human cancers, specific targeting of oncogenic pathways provides a potentially effective therapeutic strategy.
Homeostatic regulation of neuronal signaling pathways provides a mechanism whereby common founder mutations could manifest diverse symptoms in different patients.
SREBP regulation of the lipid and sterol biosynthesis pathways provides a clear example of this in our data.
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Studying pathways provides an understanding of linkages between the land sources and delivery in catchment rivers.
Determination of axonal pathways provides an invaluable means to study the connectivity of human brain and its functional network.
In contrast, Adaptation Pathways provides an analytical approach for exploring and sequencing a set of possible actions based on alternative external developments over time.
Therefore, cross-regulation between the AR and ERK signaling pathways provides an attractive therapeutic target in molecular apocrine breast cancer.
Furthermore, increasing scrutiny and accelerated approval pathways provide a driving force to be even more efficient with limited regulatory resources.
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