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Different trafficking pathways passing through the endosomes are coordinated by the ENTH/ANTH/VHS adaptor protein superfamily.
The probability of a signal to pass through the link of node i and j is then proportional to the number of pathways passing through this link.
Given a weighted gene network and a gene in this network, the goal of an inference algorithm is to identify the potential regulatory pathways passing through this gene.
Consider, as an example, the case of a vertex j connected to i with a couple of pathways passing through k and h.
According to the concept of load scores from [ 2], we computed a load score of a reaction from the average number of pathways passing through the reaction, in comparison to the number of pathways for all metabolites in the network.
Several of these studies used the DT model and showed pathways passing through the SCPs and running ipsilaterally towards the cerebral cortex (Salamon et al. 2007; Habas and Cabanis 2007a, b; Jissendi et al. 2008; Doron et al. 2010; Anderson et al. 2011; Hyam et al. 2012).
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Studies on sleep and locomotor activity in mice [22], [33] and rats [34] with SCN lesions have used animals that were behaviorally arrhythmic in LD, suggesting that pathways required for the suppression of activity ("masking") by light were interrupted, either through collateral damage from the lesions or because these pathways pass through the SCN.
Inhibition of the parasympathetic nervous system arises from the frontal cortex, and the pathways pass through the amygdala and then to the nucleus tractus solitarii and nucleus ambiguus.
This dissociation pathway passes through a singlet transition state TS1/s with a barrier height of 40.64 kcal/mol and reaction energy of 34.58 above the initial reactant on the doublet potential energy surface.
In normal fibroblasts the canonical pathway passes through ALK5 which phosphorylates transcription factors Smad2 and 3.
If the shortest path between most of the genes in the pathway passes through the node, Betweenness is high.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com