Sentence examples for pathways outside of from inspiring English sources

In fact, the results of our study support a mechanism whereby PHD3 silencing by PHD3 CpG island methylation affects pathways outside of the conventional hypoxic response pathway.

56, 57 Because RANKL is expressed systemically, blocking RANKL with denosumab may interfere with RANKL-mediated pathways outside of bone.

All pathways outside of the area represented in the center of Figure  3 are significant at a threshold of p = 0.05.

Finally, ACL KD counteracted stem cell characteristics induced in diverse cell systems driven by activation of pathways outside of Ras-MAPK signaling.

This result suggests that the expression of YKL40 is likely to be regulated by other pathways outside of AR at the translational level.

It is not yet clear whether aging is a cause or consequence following purely epigenetic changes or alterations affecting metabolic or signaling pathways outside of the nucleus.

For each cell in the table, in the parenthesis is the number of perturbed member genes overlapping between the significant KEGG pathways; outside is the significance of this overlap between KEGG pathways.

Does the gene product being annotated function within the pathway or outside of the pathway to start or stop or change the rate of the process?) ○ If it cannot be determined whether the gene product is involved in the process itself or instead in regulation of the process (this can happen if the process is not well defined), then biocurators should annotate to the parent process term.

Other studies in mammalian cells have shown that similar phenotypes can be caused by loss-of-function or gain-of-function mutations that force a signaling pathway outside of its normal range.

A requirement for PIWIL4 in somatic cell DNA methylation extends previous reports showing a role for components of the piRNA pathway outside of the germline.

In addition, Gal-3 is secreted via nonclassical pathway outside of the cell independent on the classical secretory pathway through the endoplasmic reticulum/Golgi network thus being found on the cell surface or in the extracellular space [ 10].