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Besides autophagy, the cellular response to stress involves numerous other pathways, of which, the most common and important is inflammation.
In an alternative approach, the microbial production of pHS can be envisioned by linking together a number of different metabolic pathways, of which those based on using glucose for carbon and energy are currently the most economical.
Given that to a first approximation the cortex is often viewed as being built from a dense reciprocally interconnected network of corticocortical axonal pathways, of which there are typically 1010 in a human brain it is natural to develop a continuum phase model, along the lines described by Crook et al. [240].
While it is evident from the literature that oxidative stress can indeed be a driver for many NP-induced effects [126], the last decade of research showed that NP have the ability to act via multiple pathways of which the induction of oxidative stress is one.
Wnt proteins are believed to signal through three distinct pathways, of which the canonical Wnt/β-catenin cascade is the best understood.
In mammalian cells RACK1 serves as a scaffold protein for numerous components of diverse signal transduction pathways, of which PKCβII is the most recognized [40].
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Depending on the nature of the metabolic pathway of which a pacemaker enzyme is a constituent, the manner in which the alterations are elicited may be distinguished.
Caspase-8 is an initiator enzyme in the Fas-mediated pathway of which the downstream executioner caspase-3 is a physiological target.
This undergoes a maturation process involving fusion with multiple compartments of the endocytic pathway, of which the last station is the lysosomes [1].
The best-characterized signaling cascade in Schistosoma mansoni is the TGFβ/Smad pathway, of which essential members were identified and characterized [11].
Genes in the caspase-dependent apoptosis pathway, of which caspase-7 is a part, are critical in mammalian brain and neuronal development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com