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On the other hand, the positions and sizes of compartments might differ between pathways of the same organism.
To address this issue, we have analyzed the levels and biological activities of IFN-α/IFN-γ in alternative regeneration pathways of the same species.
In addition, the best pathways of a certain substrate in Query 5 and not found in the best pathways of the same substrate in Query 2 have similar enzyme functions but dissimilar enzyme sequences.
These parallel pathways of the same sign may increase the system's robustness [ 54], but also resistance, for example, when cancer cells do not respond to (single) drugs because multiple pathways may still transduce an (aberrant) signal [ 55].
Another particularity is that while the positions of elements common to different organisms are conserved within a pathway, their positions might differ between different pathways of the same organism.
To estimate a p-value for significance of this pathway, we iteratively compute similar scores 10 times on randomly generated pathways of the same size as that of pathway P. The frequency of scores that are larger than Sp is used as the significance p-value of pathway P to describe its dysregulation in one specific brain region.
Similar(54)
In order to construct a complete mevalonate pathway, the upper semi-pathway of the same bacterium, Streptococcus pneumoniae, was recruited.
Thus, inactivation of a single node can be buffered by the use of alternative pathways to the same end product.
If single- and double-event unbinding patterns were simply two competing pathways out of the same bound state, then the downward shift in rupture force distribution would not be observed for the iLOV unfolding forces.
Pathway analysis of the same gene cohort identified the 'ubiquitin-proteasome pathway' (p-value = 0.025) and the 'p53 pathway' (p-value = 0.041) as being enriched (Supplementary file 3).
For example, genes involved in multiple pathways might introduce bias in different pathways, different definitions of the same pathway in different knowledge bases can affect performance assessment in terms of power and true positive/negative rate.
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CEO of Professional Science Editing for Scientists @ prosciediting.com