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This information has also been used as a way to identify pathways of response, at the molecular level, that are responsible for toxic outcomes.
Functionally, many of the SRSF10-verified alternative exons are linked to pathways of response to external stimulus.
Presumably, adipose tissue and its products may have some impact on numerous pathways of response to trauma, sepsis and stress.
Systems analysis also provided insight into the major pathways of response and adaptation to these threats, and the principal drivers of these pathways.
A systems dynamics analysis was conducted to identify key pathways of threat to provision and emerging pathways of response and adaptation.
Functional genomics approaches can then be used to assess the biologic significance of the target genes and their protein products in biologic pathways of response.
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Second, APEX1 (another gene in our dataset with a high expression in T lymphocytes) is an element in a pathway of response of a target cell to granzyme A, a protease released by cytotoxic T cells and natural killer cells.
Thus our data show that a methylation change found in adult smokers and implicated as functionally important in AHRR, a gene involved in a key pathway of response to tobacco smoke components, is already present at birth in newborns due to maternal smoking in pregnancy.
In spite of that, there were only few attempts to design a common frame of references to understand the complex mutual interactions between the various pathways of inflammatory response and of thyroid tumor induction and progression.
Furthermore GSTs have cellular physiology roles such as regulators of cellular pathways of stress response and housekeeping roles in the binding and transport of specific ligands [28].
Moreover, polymorphisms of genes that are involved in the pathways of immune response and inflammation are also associated with aspirin hypersensitivity in asthma [21], [25].
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