While different models exist to describe the development pathway of memory T-cell populations (46, 47), most agree that induction of the TCM subset leads to long-lived populations residing within secondary lymphoid tissues.
The reward-related enhancement of episodic memory could be explained by the modulatory effect of the dopaminergic pathway on memory-related brain regions.
Memory T cells can therefore play critical roles in propagating and perpetuating autoimmune disease and in mediating allograft rejection, although the precise pathways for regulation of memory immune responses remain largely undefined.
These data clarify the core features of CD8+ T cell memory following vaccination with adenovectors and indicate a conserved pathway for memory development shared with persistent herpesviruses.
Although features and cellular pathways of learning and memory are highly similar in this diverse group of species, there are also subtle differences.
In 2009, Dr Dani's team published a study examining how nicotine supercharges the formation of memory pathways.
Further studies are needed to decipher the nature of the receptors and the exact signaling pathways involved in alloreactivity of memory T cells.
Increasingly, the number of potential guidelines applicable to a given patient at a given point on the care pathway becomes a problem of memory and prioritisation for the clinician, let alone the patient.
The finding clearly suggests that activation of the canonical Wnt pathway leads to generation of memory CD8 T cell population during initial immunization, ensuing in ameliorated protective immunity upon further challenge with the same pathogen.
Theoretically, a complete connectome of an individual's brain would constitute a copy of the pathways between every memory, thought and experience that person had ever had.
All these findings suggest the participation of insulin pathway in memory formation, although the responsible mechanism has not been clarified.
