Sentence examples for pathways of internalization from inspiring English sources

Additionally, rottlerin does not cross-inhibit clathrin- and caveolin-mediated endocytotic pathways of internalization, consistent with direct uptake inhibition by rottlerin.

However, clathrin-dependent and -independent pathways of internalization may not be as distinct as previously thought [30], [31].

It will be interesting to explore the possibility of this mechanism as a new and general pathway of internalization of proteins such as the proteins with transduction domains, homeoproteins, Tat and toxins.

Anchoring on selected surface determinants offers mechanisms to boost the uptake and control the rate and pathway of internalization, subsequent trafficking, and fate of nanocarriers.

Rejman et al. (2004) reviewed a number of different endocytic pathways for internalization of a variety of substances, including phagocytosis, macropinocytosis, clathrin-mediated endocytosis, and caveolae-mediated endocytosis.

The characterization of peptides-membranes interactions is fundamental to understand the pathways of peptide internalization and their effect on membrane permeability.

However, because PrPC endocytosis was also affected by dominant negative Dyn K44A we could not discriminate whether the raft-dependent pathway of PrPC internalization was Dynamin-dependent or whether a clathrin-mediated pathway was also involved.

We tested for the presence of a NCE pathway of EGFR internalization in a panel of cell lines and found that five of nine lines displayed EGFR-NCE (Table I and Supplementary Figure 9).

Other studies have shown that PAMAM G4 and the branched PEI were predominately internalized by cholesterol-dependent pathways, whereas internalization of linear PEI appeared to be independent of clathrin and cholesterol [49].

The understanding of internalization pathways of lipo- or polyplexes is crucial for engineering successful reagents for nonviral gene transfection.

Semenov et al. [31] demonstrated that Dkk1 inhibition of Wnt signaling is independent of LRP6 degradation, while Yamamoto et al. [32] reported that Wnt3A and Dkk1 regulate distinct internalization pathways of LRP6 to fine-tune Wnt signaling, and that clathrin-dependent internalization of LRP6 is required for the ability of Dkk1 to inhibit Wnt/LRP6 signaling.