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Because the intermolecular handshakes of BCL‐2 proteins are so critical to controlling cellular fate, we undertook the development of a toolbox of peptidic ligands that harness the natural potency and specificity of BH α‐helices to interrogate and potentially medicate the deregulated apoptotic pathways of human disease.
To the best of our knowledge, this is the first report that knocking down expression of one gene switches differentiation pathways of human myeloid leukemia K562 cells.
Sites and pathways of Human Leukocyte-Antigen (HLA -associated polymorpHLA -associatedhave been identified through the analysis of polymorphismsvel data, but the full extent of inmune escape pathways remains incompletely characterized.
To provide a better understanding of complex regulatory mechanisms that involve miRs, we computationally determined miRs that are significantly associated to expression changes of genes involved in signaling pathways of human gliomas.
The field of human embryonic stem (hES) cell research, although young, holds a potential for advancing our understanding of the mechanisms and pathways of human development and may provide an unlimited source of human neuronal cells for basic and applied research, therapeutic drug testing, and tissue repair or replacement.
(A) KEGG pathways of human myoblast differentiation, (B) KEGG pathways of human myoblast differentiation with TNF-α exposure.
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The alimentary tract and metabolic pathways of humans appear designed for intermittent ingestion of nutrients a few times a day.
Fungal biosynthetic pathways of human-essential amino acids are in general identical or almost identical to the respective pathways operating in bacteria or plants.
The effectiveness of the regulatory genomic signatures is demonstrated via analysis of promoter sequences for genes in DNA repair pathways of humans.
Contamination of drinking water, house dust, foods, and fish products are the possible major exposure pathways of humans to PFCs (Lau et al. 2007).
The effectiveness of genomic regulatory signatures that are based on SIG1 and SIG2 was addressed by analyzing promoter sequences for genes in DNA repair pathways of humans.
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