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Although the positive overall RHs are comparable to those of other studies, the mediating variables and pathways of effects seem dissimilar in this sample from a secular environment.
In contrast, we found only plant-species richness effects but no effects of legume presence on aphid and parasitoid richness and densities in a community-level study at the same field site [11], underlining the importance of life-history studies to detect different pathways of effects of plant species loss on associated biodiversity.
This article emphasizes the need to link molecular responses with cellular and tissue level responses to establish pathways of effects for EDCs.
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36 37 Further work to examine potential pathways of effect is required.
For example, multipollutant combinations could be discriminated using prior knowledge of hypothesized biological pathways of effect [ 10] (e.g., inflammation) or known emissions sources (e.g., traffic) [ 11].
The HCM and PCS modules are underpinned by behaviour change theory to initiate the intended pathway of effect.
Phosphatase and tensin homologue deleted on chromosome 10 expression and LiCl treatment may thus share a common pathway of effect involving Cdc42 activation and GSK3 β Ser9 phosphorylation in promotion of PARP cleavage and apoptosis.
Thus, balancing selection would be more likely to act on different signaling pathways of opposite effects on a trait, rather than on different downstream pathways of opposite effects within a single signaling pathway.
Figure 1 The main pathways of the effects of EPO.
To analyze pathways of the effects, mediator analyzes will be computed.
In Fig. 3a, two pathways of local effects of irritants and their mutual interaction are schematically illustrated.
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