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Multiple Pathways of DNA Repair and Their Possible Roles in Mutagenesis.
Genome engineering with targetable nucleases depends on cellular pathways of DNA repair after target cleavage.
Rothkamm, K., Kruger, I., Thompson, L. H. & Lobrich, M. Pathways of DNA double-strand break repair during the mammalian cell cycle.
Predicting enzyme action is the first step in the development of a large knowledge base to envision the metabolic pathways of DNA replication and repair.
During the past three decades, understanding of cancer has increased with the discovery of oncogenes, tumor suppressor genes, pathways of DNA damage and repair, chromatin remodeling, cell cycle regulation, angiogenesis, and responses to hypoxia, and recent glimpses into the molecular basis of metastasis and cancer stem cell biology.
This enzyme catalyses hydrolysis and transfer of nucleotide-containing substrates in metabolic pathways of DNA, RNA and carbohydrates.
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Thode, S., Schäfer, A., Pfeiffer, P. & Vielmetter, W. A novel pathway of DNA end-to-end joining.
A combination of a temperature spike and electron/hole interactions may be a dominant pathway of DNA damage.
Nonhomologous end joining (NHEJ) is the primary pathway of DNA double-strand-break repair in vertebrate cells, yet how NHEJ factors assemble a synaptic complex that bridges DNA ends remains unclear.
Targeting nucleic acids using small molecules routinely uses the end products in the conversion pathway of "DNA to RNA, RNA to protein".
Human apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional protein which is essential in the base excision repair (BER) pathway of DNA lesions caused by oxidation and alkylation.
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