There were three major pathways of discoveries between 1990 and today.
The pathway of discovery that has now re-opened questions about Wnt signaling in breast cancer is a remarkable one that has meandered among diverse fields of modern biology.
Many companies have made a strategic migration away from the tried-and-true (but also too long and costly) pathways of drug discovery toward novel approaches that promise unprecedented speed and precision.
The second of these pathways to discovery is a more novel approach of generating and then sifting MPS results as the raw material to allow the generation of clinical hypotheses, which are in turn used to design clinical experiments to discover the phenotype that is associated with that genotype.
In addition to the work done at the NCGC, other elements in the Roadmap's theme of "new pathways to discovery" include biological pathways, structural biology, bioinformatics, and nanomedicine.
The Roadmap identifies the most compelling opportunities in three arenas: new pathways to discovery, research teams of the future, and reengineering the clinical research enterprise.
The pathway of drug discovery from gene and therapeutic targets to breakthrough medicines provides an extraordinary adventure that often includes high risks, creative insights, relentless perserverance, goal-oriented focus, interdisciplinary teamwork and a bit of good luck.
There are tremendous opportunities in the field of combinatorial discovery of thin film materials, as it enters its golden age along with the Materials Genome Initiative, which aims to change the pathway of materials discovery.
We apply the method to the TCGA collection of 145 glioblastoma samples, resulting in extension of known pathways and discovery of new functional modules.
