First, allelic series experiments in which adaptor binding is abrogated in order to abolish specific effector cascades may result in induction of alternate signaling pathways, complicating assignment of developmental function to a single intracellular pathway.
It is suggested that the RA NTA framework may provide a general tool to define mechanistic pathways and biomarkers of developmental toxicity that may be used in alternative in vitro assays for the detection of embryotoxic compounds.
The abnormal proteins are not related to a previously identified neurological disease pathway but consist of developmental neuronal/glial/axonal growth, cell metabolism, cyto-architecture and apoptosis components.
The paper is "definitely significant" because it gives "new insight into the early pathways of patterning," says developmental biologist Rebecca Burdine of Princeton University.
As such, key modulators of developmental pathways (e.g. the Notch pathway) are of considerable clinical interest for their potential therapeutic value (Pannuti et al, 2010).
Animal experiments revealed that intrauterine inflammation resulted in structural lung impairment [13] and disturbance of developmental pathways in the lung, impairing growth factors and branching morphogenesis [6].
In the case considered in this work, this is a change in shoot architecture using the material afforded by the natural variability of developmental pathways of the plant modules.
These studies indicate that affective neuroscience can inform understanding of developmental pathways to depression and identify altered emotional processing among youth at high risk.
Kim suggested that the root cause of ageing is the "drift", or mistiming, of developmental pathways during the ageing process, rather than an accumulation of cellular damage.
We discuss maternal control of the early embryonic epigenetic landscape, selective usage of enhancer clusters via 3D chromatin contacts leading to activation of transcription factor networks, and conserved regulation of developmental pathways by specific DNA demethylation of key regulatory regions.
