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The orderly development of an organism depends on a process called cell determination, in which initially identical cells become committed to different pathways of development.
Instead, human history, at virtually every scale, appears to embody a large degree of contingency and multiple pathways of development.
B cells follow two functionally distinct pathways of development: a classical germinal center (GC) T-dependent pathway in which diversification and maturation generate a slow, but virtually unlimited high-affinity response to cognate antigens; and a marginal zone (MZ) T-independent pathway providing a first line of 'innate-like' defense against specific pathogens.
But time and time again, the real lessons of how this contribution actually worked -- the genuine pathways of development change -- have been lost or ignored.
Most recently, an analysis of Cbl inactivation effects on the T cell developmental defects observed in SLP-76 mutant mice suggested that activation of Vav1 might be a critical event in rescue of alternative pathways of development[16].
This may imply racial differences in the pathogenetic pathways of development of DM.
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To simulate tissue differentiation and the pathway of development of the curing cells during the healing process, a mechano-regulation theory on deviatoric strain is introduced.
Radiation processing initiated also about 40 years ago yielded a similar pathway of development in the beginning, mostly in the radiation crosslinking of polymers and in the radiation sterilization of polymer products.
The pathway of development of novel therapeutic agents is well established.
Unlike GLP-1/Notch sINX-8/INX-9 INX-14/INX-21-14/INX-21 INX-8/INX-9 INX-14/INX-21 entry into the meiotichannelsy of development are gametogenesis.
This paper applies these concepts to the analysis of the pathway of development of China's NCMS system over three and a half decades.
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