Sentence examples for pathways of aggregation from inspiring English sources

Using aggregation as readout is intuitive since if any part of the pathways of aggregation is toxic, then reducing the eventual product of large readout aggregates could also be considered reducing the intermediate toxic species.

As the pathways of aggregation are manifold, good understanding of the mechanisms behind is essential.

Thus, the seeding process is one way of evaluating the structural assembly of oligomers and consequently pathways of aggregation as reported previously [50] [54].

It is important to understand the pathways of aggregation because if some oligomers are indeed formed as 'off-pathway' products, their half-life can be significantly longer than that of the 'on-pathway' oligomers, resulting in prolonged toxicity to neuronal cells.

Also, modifying the pathways of aggregation remains a viable therapeutic approach as does facilitating mitochondrial health and function.

Altering the specific pathways of aggregation is a potential therapeutic strategy which may not decrease the total amount of aggregation but could decrease neurotoxicity.

Recent advances are being made and assays developed which will help in studying this pathway of aggregation, monomer addition, and isolating specific aggregate species [ 98].

Combined with ThT fluorescence, SDS-PAGE, and EM experiment, we propose that geniposide may modulate the folding pathway of aggregation-prone polypeptides and thereby prevents their assembly into toxic aggregation products.

The data show that different concentrations of fatty acids seem to induce multiple pathways of Aβ42 aggregation.

Therefore, there is a need to explore whether physiological lipids and fatty acids can dictate similar multiple pathways of Aβ aggregation and generate stable oligomers.

Based on these previous reports, it is clear that by choosing appropriate concentrations of SDS as well as the SDS: Aβ42 ratio, one can induce different pathways of Aβ42 aggregation.