Based on the known functions of the protein encoded by these mRNA, pathways of regulation affecting behaviour and partly controlled by miRNAs can be identified.
Even though the pathways of TLE1 affecting cancer growth are not clear, our data reflect that the strong sex difference of TLE1 methylation might explain partially that AML and synovial sarcoma are a little more common in males than females.
Our final analysis evaluated how different pathways of loneliness affect pet ownership in Wave 5.
An initial exploration of pathways affected shows that some of the pathways and transcription factors implicated by the transcriptional data are common to both mutants.
Consistent with the thymic atrophy and changes in thymic lymphocyte populations, the constellation of pathways affected suggests dysregulation of T-cell development in the thymus and function of mature T cells upon release.
The majority of pathways affected by the high-fat diets exhibit opposite regulation during the early and the late phase of the high-fat feeding time-course.
This similarity was further confirmed by a significant overlap of pathways affected by the HCV transgene and the Mdr2-KO mutation revealed in the current study (Table S2).
A list of pathways affected under stress conditions are given in Supplementary Table S5.
The two heatmaps in Figure 2 look surprisingly similar, suggesting that the majority of pathways affected by DNA methylation in cancer are common to multiple cancer types.
Grouping the essential genes sensitized to each chemical by gene ontology allowed us to build a network of pathways affected by the four chemicals.
