Sentence examples for pathways most likely from inspiring English sources

We have recently proposed a radically different mechanism that Aβ proteins are internalized by neurons via non-endocytotic and energy independent pathways, most likely due to their ability to biophysically interact with the neuronal membrane [13].

In conclusion, the current study demonstrates that Aβ40 is internalized by neurons primarily via non-endocytotic and energy independent pathways, most likely due to its ability to biophysically interact with the neuronal membrane.

The proliferative and survival properties of the Jak/Stat and PI3K pathways most likely play a central role in AML leukemogenesis as well as in refractoriness and resistance to clinically used DNA damaging agents.

In order to explore the hypothesis that HCV proteins may accelerate inflammation-associated liver carcinogenesis, and to identify and characterize the signaling pathways most likely to be affected, we crossed one of the existing HCV-Tg models, which produced detectable levels of HCV proteins [9], with the Mdr2 knockout (Mdr2-KO) mice, a model of inflammation-associated HCC.

ROS formation in the dysfunctional mitochondria, decreased mitochondrial membrane potentials, and the activation of apoptotic pathways most likely causes hair cell death; however, other pathways are also hypothesized.

A typical example is an enrichment test to prioritize pathways most likely to be affected in a given high-throughput experiment.

These data suggested that NSFs stimulate an active transport pathway, most likely transcytosis, in addition to increasing paracellular flux.

The SC cuneiform nucleus pathway most likely plays a role in defensive or fear-related cardiovascular responses58,59, which are beyond the scope of the present discussion.

In contrast, GCP-WD is absolutely required for γ-tubulin recruitment and seems to function more proximal to the γTuRC in the recruitment pathway, most likely downstream of Cep215/pericentrin.

Mutational analysis demonstrated that transcription of NR1 and NR2B are regulated by the c-AMP signaling pathway, most likely through the binding of CREB and its activation by signal-dependent phosphorylation [18], [39].

In addition, we observed an 11.6-fold increase in the expression levels of suppressor of cytokine signaling (SOCS) 3 mRNA after TURP treatment (Fig. 1E; t(12) = 7.6, p<0.0001), indicating the activation of the JAK/STAT signaling pathway, most likely by IL-6 [41], which is involved in the induction of HAMP and zip14 mRNA expression.