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Some effectors of the S100A4-activated pathways might also lend themselves as foci of therapeutic interest.
As blockade of FGFR3, NOTCH1 and CTNNB1 pathways impaired basal cell proliferation, we reasoned that inhibition of these pathways might also promote cellular differentiation.
Other pathways might also have contributed to high level resistance, like the arginine deiminase pathway, catalase, peroxidase, protein degradation and DNA repair.
Transcription analysis indicated that the TLR signalling pathway might play a major role in the innate immune response and the major histocompatibility complex (MHC -I and MHC -I andigen presentation pathways might also both exist in vertebrate fish.
These results suggested that ursolic acid was capable of inhibiting multiple critical kinases in tumor progression, and the facilitation of inhibition of these signaling pathways might also be responsible for the enhanced effects when combined with oxaliplatin.
The SSGs were regulated in either a sucrose-dependent or -independent manner, or both, and other regulation pathways might also be involved in the expression of SSGs such as SSI and BEIIa.
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We reasoned that mitochondrial aggregation caused by blockade of the Arf6-based pathway might also induce RIRR-like phenomena in single cancer cells.
Inhibiting the pathway might also result in differentiation of cancer stem cells [15].
Activation of the cranial parasympathetic vasodilator pathway might also influence both central trigeminovascular neurons, and the dural microenvironment, potentially by evoking neuro-inflammatory mechanisms.
The H2B regulation pathway might also involve the lactate dehydrogenase (LDH) [28].
In addition to the Rap1-Rapl-Mst1 pathway [7], [10], [26], the Mst1-FoxO pathway might also be important for T cell trafficking.
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