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Targeting core stem cell pathways may offer improved therapeutic approaches for advanced cancers.
Novel therapies targeted against specific molecular pathways may offer superior efficacy and less toxicity than conventional therapies, but initial clinical trials of molecular targeted agents in brain cancer therapy have been frequently disappointing.
These analyses suggest that therapeutic targeting of specific altered oncogenes may be too narrow an approach for drug development, but rather targeting nodes that reside downstream of these pathways may offer broader acting therapies [1], [2].
Interactions between intracellular signaling pathways may offer an explanation.
Induction of these pathways may offer a rational therapeutic strategy for a number of these diseases.
Targeting these novel pathways may offer newer strategies of management of adverse pregnancies.
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Probing the disassembly pathway may offer insight into the mechanisms through which various subunits self-assemble into complexes.
Our findings suggest that NPs engineered to exploit the cell transcytosis intracellular trafficking pathway may offer a more safe and efficient route for siRNA delivery.
Specific inhibition of PP1 in this pathway may offer therapeutic approaches to disorders with increased beta-catenin signaling.
This pathway may offer attractive BCSC targets for cancer therapy.
Thus, interference with IL-6 pathway may offer opportunities for ovarian cancer therapy.
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