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These results suggest that mitochondria represent a nexus at which the autophagy and apoptosis pathways may interact.
Similarly, Dicer and other Argonaute proteins are also localised in the chromatoid body [26], indicating that these pathways may interact.
In a similar manner, p38 and Smad 3 signaling pathways may interact as it appeared that inhibition of p38 augmented phosphorylation of Smad 3.
The frequency of MYC activation and loss of RB pathway function in human HCC suggests that these two pathways may interact during tumorigenesis in the liver.
Furthermore, recent studies have suggested that SERCA2a and the PI3K/GSK3β pathways may interact either directly or through a Ca2+-mediated process [43].
In general, our findings support the idea that the etiology of pulmonary hypertension in sickle cell disease is multi-factorial, and that pro-inflammatory and angiogenic pathways may interact with the degree of hemolysis in contributing to the development of pulmonary hypertension.
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Our results suggest that RNA editors may be an important regulator of aging in humans and that, when evaluated in C. elegans, this pathway may interact with the RNA interference machinery to regulate lifespan.
It is also interesting to note that the circadian rhythm pathway may interact with the aforementioned Polycomb complex via EZH2 activity, since the mammalian EZH2 gene product binds to the PER1 and PER2 promoters [62].
Pathway may interact with the other pathways in a specific condition, but dot not influence each other in another condition.
The cold stress-signaling pathway may interact with other signaling systems of, for example, ABA, salt, and drought [ 19].
Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation.
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