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Drugs nonexclusively affecting parallel pathways may act according to Bliss independence.
The same behaviour has been observed in migraineurs after beta-blockers prophylaxis, showing that different drugs, by modulating separate pathways, may act on the same pathophysiological mechanism.
Recent studies suggest that variation in the use of erythrocyte invasion pathways may act as a mechanism that facilitates immune evasion [13].
We hypothesized that the combined effect of inhibiting these three platelet activating pathways may act to significantly inhibit thrombus formation.
It has also been described that Kit-dependent and IgER-dependent pathways may act in concert to provoke mediator release in MC (41).
Taken together these findings suggest that TLR4 signaling pathways may act as mediators of increased inflammation in high malignancy epidermal tumors.
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This study also strengthens the hypothesis that rapamycin, everolimus and analogues acting on the mTOR pathway may act as possible geroprotectors effective in HGPS and normal aging [ 45, 46].
Drugs inhibiting parts of the same linear pathway may act according to Loewe additivity [17].
Our previous finding that the PINK1/Parkin pathway promotes mitochondrial fragmentation led us to propose that this pathway may act to segregate damaged portions of the mitochondrial reticulum for turnover through an autophagic mechanism [15].
Under physiological conditions, the PPARG pathway may act as a sensor of the balance between oxidative phosphorylation and aerobic glycolysis, and shift the balance between neural cell proliferation and differentiation accordingly.
These data, combined with our data on Ncs2, Nup60, and Pom152, further implicate the nuclear pore in proper assembly of the SPB and suggest that the urmylation pathway may act in conjunction with nuclear pore components to regulate SPB size.
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