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ToC is displayed as a causal pathways map with a number of key elements.
Described in Table 6, the 9 Pathway Distiller pathways map to four different HPD similarity groups (■, ▲, ●, and ►).
Of the cytokine- activated pathways, MAP kinases are especially important because they regulate the production of several mediators of inflammation and cartilage damage [ 2].
The results of a pathway enrichment can further be visualized in metapathways (e.g. the 'metabolic pathways' map), together with mRNA expression data and enriched sub-pathways.
Images for the Metabolic Pathways map (tgo01100) were obtained for each sample and a GIF file was created using the convert program.
Despite MAP's successful siege against the intestinal barrier as evidence of its infiltration into lamina propria macrophages, the exact genes and pathways MAP employs within the intestinal epithelium remains a black hole in our understanding of overall pathogenesis[ 17].
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All the pathways mapped using membrane protein data were already mapped by spore protein data.
These pathways control the rate of protein turnover at the level of transcription (calcium/calmodulin pathways; MAP-kinase pathways), translation (PI3K Akt mTOR), degradation (FOXO E3 ligase proteasome and NF-κB pathway) or a combination of these (AMPK PGC-1α).
The top two enriched pathways mapped to the WNT and TGF-beta signalling pathways (Table 2).
Figure 4 KEGG pathway map for benzoate degradation in P. putida F1.
The results are summarised in the pathway map shown in Fig. 3.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com