Sentence examples for pathways making it from inspiring English sources

As a cytoplasmic HDAC, HDAC6 has been implicated in the regulation of many cancer-associated cellular events and signaling pathways, making it an attractive target for cancer chemotherapy (Aldana-Masangkay and Sakamoto, 2011; Dallavalle et al., 2012).

The hydrolysable C3 protein is the converging point for all three complement activation pathways, making it the central player in the complement cascade [15].

While these findings demonstrate an etiological heterogeneity for ASDs, many of the genes appear to interact at the level of molecular pathways, making it likely that mutations of one ASD-implicated gene may affect the function of others [50].

Based on a linkage study [36] the ELTD1 gene has been implicated in neuropeptide signaling and signal transduction pathways, making it an important candidate for genetic risk to cannabis use disorders.

So far, no information is available on fetuin-A-specific cell surface receptors and intracellular signaling pathways making it difficult to assess the molecular mechanisms underlying fetuin-A-induced repression of ADIPOQ expression in adipocytes as well as fetuin-A-mediated induction of cytokine expression in monocytes and adipocytes.

Atg1 activity is regulated by nutrient-sensing pathways, making it a pivotal signal transducer in autophagy.

The identification of distinct molecular requirements for each of these pathways makes it clear that mammalian cells have evolved more complex targeting mechanisms and routes than previously anticipated.

Freshly carved neural pathways made it possible to ride from Dalston to Denmark Hill; to visit Goldsmiths college by way of New Cross Gate; to see where William Blake was married or where Freud died.

The complexity of human metabolome, especially the redundant use of the same metabolites in many biochemical pathways, makes it impractical to obtain a mechanistic understanding of disease states and drug responses based on metabolite concentrations alone.

Established rules and regulatory pathways made it easier for companies to develop their products for market and encouraged investors "to believe in the science" and to spend the money needed to bring products to market, she says.

In vivo approaches, including transgenic mouse models, are able to embrace globally what happens during skin wound healing but the complexity provided by the coexistence of many cell types and many sub-cellular pathways makes it difficult to identify and address specific questions about TGF-β1 [44], [48], [66], [66].