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As with allowing neutral mutations, the effect of allowing double mutations on the number of accessible pathways is more pronounced when back mutations are allowed.
We suggest that combined targeting of oncogenic pathways is more likely to be effective in the treatment of lung cancers and lymphomas.
For nascent glycoproteins with N-glycans late in the sequence (e.g. the α1-antitrypsin variants analyzed here), partitioning in alternative chaperone pathways is more likely to occur [8].
Because biological interpretation of pathways is more straightforward, we report only on KEGG results.
However, cross-talk between p53 and the mTOR signaling pathways is more complex.
It has been shown, that inhibition of the Ras/Raf/Mek/Erk and PI3K/Akt/mTOR pathways is more effective and induces synergistically effects [ 36, 39].
Similar(45)
In contrast, Mg2+ influx pathways are more complex.
However, those for the degradative pathways are more readily obtainable.
Therefore, when the cost of hydrogen production is included, photoautotrophic pathways are more efficient.
Ruminant-based supply systems are primarily affected by grazing limits; monogastric pathways are more affected by cropland limits.
This means that some synaptic pathways are more favoured than others.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com