Exact(4)
As the number of oncogenic mutations required for cancer after the original fitness increase (C D) increases further, greater predominance of mutator pathways is expected.
Conversely, a pathway that receives signaling inputs from other pathways is expected to be more constrained in the downstream portion.
Skp2 gene expression is regulated by the Notch, IKK/NF-κB, or Akt signaling pathways, thus inhibition of these oncogenic pathways is expected to shut down Skp2 gene expression.
Therefore, in silico prediction of unknown pathways is expected to support the experimental characterization, leading to benefit not only drug discovery and health care but also agricultural and environmental issues.
Similar(4)
Many metabolic pathways are expected to be truncated or completely removed.
Microorganisms containing only desired catalytic and replication capabilities in their metabolic pathways are expected to offer efficient processes for chemical production.
Thus, for globular proteins, which have much higher variation in local structure and topology, parallel pathways are expected to be the exception rather than the rule.
Clearly, the more interactors were shared, the more common pathways were expected.
Related(1)
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