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However, the kinetic response of these pathways is currently unknown.
A mechanistic understanding of controls on partitioning among these pathways is currently lacking.
The identity of these mTOR-independent pathways is currently unknown.
The identification of these molecules and pathways is currently under investigation.
However, the exact mechanism of survivin suppression by sorafenib, which could be a direct effect or mediated through other signalling pathways, is currently being investigated.
Tumor necrosis factor (TNF) alpha is a potent stimulator of catabolic pathways, whereas its influence on anabolic pathways is currently unknown.
Similar(47)
Cell survival and apoptotic protein pathways are currently being monitored with LCM and RPPAs at the National Institutes of Health, in phase II clinical trials of metastatic breast and ovarian cancers.
This is of particular importance as novel, more efficient and more specific inhibitors of both pathways are currently being developed [48], [49].
Although the miRNA regulatory pathways are currently unknown, the results of the present study suggest that significant functional differentiation of miRNAs occurs at different developmental stages and some miRNA regulatory mechanisms maybe similar in Porphyra and in higher plants.
These pathways are currently being studied for biomarker development.
Self-renewal pathways are currently an area of major study in myeloid malignancies.
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