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Since signalling through HER-2 pathways is believed to be involved in driving cell proliferation in ER-negative IBC and to resist anti-oestrogen therapy in ER-expressing/HER-2-positive cancers, the association of COX-2 with HER-2 expression in DCIS suggests that the carcinogenic sequalae of COX-2 overexpression originate at the preinvasive stage in breast carcinogenesis.
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Although these ascending pathways are believed to terminate in the cortex with one or several relay stations in their way, the term 'nociceptive ascending pathways' is normally used in a restricted sense to designate the neuronal tracts that connect the spinal cord with supraspinal regions, each pathway being named from the brain area at which it terminates.
Most TCS pathways are believed to involve a unique pair of SK/RR proteins [4], [5].
Depending on the type of cancer under investigation many different signalling molecules and pathways are believed to actively partake in the IL-24-mediated killing of target cells (for comprehensive reviews, see [34], [35]).
Although all pathways were believed to be important, achieving an extensive philosophical shift was required.
These pathways are believed to play important roles in the development and progression of astrocytoma.
Four major signaling pathways are believed to mediate the effects in Drosophila innate immunity.
Cellular senescence pathways are believed to have multiple layers of regulation.
Hence, complex interactions amongst different signalling pathways are believed to specify contextual responses of the cells to diverse environmental stimuli.
The cross-talk between ER and such alternative signaling pathways are believed to enable breast cancer to evade the antiproliferative effects of anti-estrogens [ 5].
The survival pathways are believed to render some types of cancer recalcitrant to PDT and alter the tumor microenvironment in favor of tumor survival.
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