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The maximum weight submatrix problem defined to find mutated driver pathways is based on two specific properties, i.e., high coverage and high exclusivity.
In fact, the comparison of two given pathways is based on their underlying sets of reactions and ignores their structure.
A representation of logical networks that is well-suited to study signal transduction pathways is based on directed hypergraphs which in turn relies on SOPrepresented logical functions [ 10].
One of the hypotheses for the initiation of survival pathways is based on the generation of reactive oxygen species (ROS) in stressed photoreceptors.
The phenomenon of cascade activation of the reprogramming pathways is based on the ability of one reprogramming pathway to transmit the signal to another pathway.
The analysis of treatment pathways is based on an approach we have developed for studying access to hospital care using register-based data [ 12].
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Many of these spiritual pathways are based somewhat loosely around Native American traditions, including the ceremonial sweat lodge.
The pathways were based on the use of biomass, nuclear, solar, wind, hydroelectricity, and geothermal as the source of energy.
Given that BCL-2 is overexpressed in many tumors, most strategies to engage apoptosis pathways are based in the blockade of anti-apoptotic members of the BCL-2 family.
Canonical pathways are based on the literature (journal article, KEGG pathways) and are used to overlay expression changes.
Ingenuity Pathways are based on a constantly curated database of published literature on gene functions and interactions (https://analysis.ingenuity.com).com
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com