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For the first time in perhaps a decade, the aisles felt like real pathways instead of Times Square on New Year's Eve.
For exomes, one could also further collapse entire pathways instead of genes.
To identify functions potentially under selective pressure, we used an innovative approach, focusing on gene pathways instead of outliers.
Furthermore, Fas undergoes a change in its functionality in oxaliplatin-resistant cells inducing survival pathways instead of apoptotic signals.
Given the importance of both the MAPK and PI3K/Akt pathways in melanoma, simultaneously targeting the two pathways, instead of either alone, may prove to be a particularly effective therapeutic strategy for this cancer.
Importantly, in a core analysis to our set of genes aiming to evaluate their biochemical relationships and possible function in the cell, we observed that the canonical pathways more represented in our screen (Figure S2B and Table S4) are also clearly represented in the previous studies [7] [10], indicating a possible overlap of signal pathways instead of a direct overlap of genes.
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Luray Caverns, which has a brick pathway instead of gravel like the others, is well-lighted by 707 lights concealed in fake rocks.
Manglik et al. selectively targeted the Gi based μOR pathway instead of the β-arrestin pathway of the opioids.
To maximize a siRNA screen's chances of success, she suggests using panels of siRNAs against multiple gene targets in a pathway instead of just one.
The large scale of PGC data has been used in two PBA studies (Duncan et al., 2014; Yu et al., 2014a), but they are both hypothesis-based and only focus on one type of pathway instead of all pathways.
In migraineurs, a reduction in mitochondrial energy would favour a metabolic shift directing tyrosine metabolism toward decarboxylation pathway instead of the hydroxylation one, leading to reduced catecholamines production and high trace amine levels in the pain matrix, and, ultimately, to the trigemino-vascular system activation, triggering the attack [1].
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