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Activation of Gαq/11 pathways increases the size of tanycyte endfeet that shield pituitary vessels and induces the activity of the TRH-degrading ectoenzyme.
This is both because a greater number of metabolic pathways increases the overall cost of signal production and because the overproduction of a single component by cheaters may be easy to ignore or may even solicit aggression towards the signaler [c.f. 9,46].
More connection between pathways increases the possibility of using an alternative pathways.
The presence of inactive or inefficient LKB1-AMPK pathways increases the metabolic changes that occur in premalignant cells [ 61].
Our findings indicate that combining the recurrence-associated pathways increases the statistical significance of patient classification according to recurrence risk.
Although not all of these SNPs have reached genomewide significance (P ), their membership of enriched pathways increases the prior for association.
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The present data show that the simultaneous action of the insulin and Sirt1-mediated pathways increased the efficiency of osteoblast differentiation.
Furthermore, in vitro manipulation of Programmed Death-1 and 2B4 inhibitory pathways increased the proliferative capacity of HIV-specific CD8 T cells.
Aberrant changes in these signaling pathways increase the nutrient uptake and metabolism necessary to fuel cell survival and proliferation (DeBerardinis et al., 2008; Hsu and Sabatini, 2008).
In the absence of FBS, interfering either of the signaling pathways increased the population of cells at the G1 phase (Figure 5C), indicating that the proliferation of the TS-like cells was dependent of the two signalings.
Do pathways increase the use of proven medical therapies for patients?
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