Notch signaling is a highly conserved pathway in evolution, which has an important role in synaptic plasticity and inflammation in central nervous system.
Notch signaling is a highly conserved pathway in evolution, which often regulates cell-fate decisions in developing nervous system and has an important role in synaptic plasticity in adult CNS [ 9- 12].
This complex and the NEC might share molecular attributes like the zinc-finger motif coming from a common ancestor when (and if) herpesvirus has hijacked this pathway in evolution (Forterre and Prangishvili, 2013).
Notch signaling is a highly conserved pathway in evolution, which is crucial for many biological processes such as development, immunology, inflammation, vasculogenesis, tumor formation, and learning and memory [ 11, 13- 17].
"If their analysis is right," Nagy says, "then it points to a whole new set of experiments that we can do to learn about how pathways change in evolution".
The Wnt/β-catenin signaling pathway is one of the most conserved pathways in organism evolution and plays key roles in embryonic development, cell growth, differentiation, polarity formation, neural development, and carcinogenesis [ 8].
Firstly, and most importantly, CGH based studies provide evidence of two distinct pathways in the evolution of DCIS and IDC.
Also, our results support the proposed preponderance of central carbon and anabolic pathways in the evolution of metabolism [ 2, 8, 27, 29].
