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The mechanism by which a normal cell progresses to carcinoma customarily involves the disruption of critical molecular pathways in cellular growth, differentiation, and development [7].
Several fluorescent sphingolipid analogs have been used as tracers of endocytic trafficking pathways in cellular models of lipid storage diseases [12].
Here, we have determined the functions of phosphorylation signaling pathways in cellular processes.
We point to reference [ 26] as a recent example suggesting competition between antagonistic pathways in cellular decision processes.
These protein domains are related to different regulatory pathways in cellular processes, such as growth, sexual/asexual development [ 42] and pathogenicity [ 43].
Moreover, our studies suggest crosstalk between NFκB and c-Jun/AP-1 pathways in cellular response to Cr VI) exposure for COX-2 induction.
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This mutation was shown to reduce the serum half-life of the scFv-Fc fragment from 10 days to 27 h by preventing the interaction of the intact Fc region with the Brambell receptor (FcRN) responsible for diverting antibodies away from the degradation pathway in cellular lysosomes (Figure 1a). Figure 1 A chimeric intact antibody and single-chain Fv-Fc (scFv-Fc) fragment.
This profile matches the proposed role of ROS as a signalling pathway in cellular differentiation.
The emerging role of the Keap1 Nrf2 pathway in cellular bioenergetics adds another layer to the broad cytoprotection which it provides.
This is consistent with an important role of the late secretory pathway in cellular copper homeostasis (Labbe and Thiele, 1999).
The roles of the NF-κB pathway in cellular survival, proliferation and the inflammatory response and of the Nrf2/Keap1 pathway in the cellular defense against chemical stress and redox perturbation are well described.
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