Sentence examples for pathways have shown from inspiring English sources

Encouragingly, small molecule inhibitors of these pathways have shown promise in clinical trials or are approved for clinical use.

Antibodies directed to proteins in both pathways have shown significant activity especially in combination with chemotherapy, and studies in the adjuvant setting are in progress.

Anti-cancer drugs targeted to specific oncogenic pathways have shown promising therapeutic results in the past few years; however, drug resistance remains an important obstacle for these therapies.

Consistent with this result, development of drugs mainly targeting glucose transport and phosphorylation steps in glycolytic pathways have shown to be a latent therapeutic strategy for reducing cancer phenotype [19], [27], [29].

Indeed, genetic variations in these pathways have shown to modify the risk for BC [ 29].

Studies of these two pathways have shown that CRC is a genetically heterogeneous disease [ 4].

Recently, the production of higher chain alcohols from 2-keto acid pathways has shown significant progress.

Expression of these receptors has been linked to functional impairment of T cells in cancer, and therapeutic blockade of these two pathways has shown clinical promise.

Targeting pathways has shown benefit for patients who express particular gene mutation, for example, epidermal growth factor receptor (EGFR) gene mutation.

Dissection of the signalling pathways has shown that ras, PI3-K and STAT were responsible for growth, scattering/survival and polarity/ morphogenesis, respectively.

Consistent with this concept, pharmaceutical inhibition of both the MEK and PI3K pathways has shown durable responses in KRAS mutant cancers in vivo.