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These metabolic pathways have only a limited capacity.
The transporters comprising these pathways have only begun to be identified.
In the social amoebas, developmental pathways have only been studied in detail in the model organism D. discoideum, where cell-to-cell communication is largely mediated by secreted signaling molecules.
Nonetheless, the action of SREBP-1 is under the regulation of liver X receptor (LXR) and these complex pathways have only recently started to be investigated in fish [ 23].
A peculiar replacement of one aspartate in this pair to histidine is observed in Aves (birds), although apoptotic pathways have only been well studied in chicken cells, and the chicken Apaf-1 has aspartates or glutamates in all positions proposed to be important for apoptosome assembly.
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The cancer secretome, namely the whole collection of proteins secreted by cancer cells through various secretory pathways, has only recently been shown to have significant potential for diverse applications in oncoproteomics.
While these so-called natural products have been targets for plant metabolic engineering attempts for many years, the immense value of manipulating the interface between committed steps in secondary metabolism pathways and those in primary metabolism pathways has only recently emerged.
Previous attempts to introduce novel hydrogen pathways had only given very low activities.
Effective pharmacological inhibitors of the Wnt pathway have only recently become available.
Although numerous extracellular phosphoproteins have been identified, the protein kinases within the secretory pathway have only recently been discovered, and their regulation is virtually unexplored.
This is likely because the kinases in the secretory pathway have only recently been discovered (Ishikawa et al., 2008; Tagliabracci et al., 2012, 2013; Bordoli et al., 2014).
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