Sentence examples for pathways have important from inspiring English sources

As discussed, EMT signaling pathways have important roles in the transformation of epithelial cells into CSCs.

Wnt signaling pathways have important functions in controlling the fate of MSCs [ 4].

Both the Wnt/β-catenin and RA signaling pathways have important roles in eye development (Fuhrmann, 2008; Cvekl and Wang, 2009; Duester, 2009).

Signal transducer and activator of transcription (STAT) proteins as well as cytokine-driven Janus kinase (JAK /STAT pathways have important roles in these processes as they frequently show alterations in their activities (Klampfer, 2008).

As evident, PI3K and STAT pathways have important role in the progression of angiogenesis; treatment of Ery5 effectively reduced the expression of pAKT, p90RSK and pSTAT3 in HUVECs and PC-3 cells starting from 6 h.

Numerous studies have shown that Akt, ERK, and JNK signaling pathways have important roles in cancerous cell proliferation, cell cycle, and apoptosis regulation in a p53-dependent or -independent manner [ 22- 24].

Therefore, the discovery of molecular targets to sensitise apoptotic signalling pathways has important therapeutic implications.

Regulation by the PRC complexes of pathways implicated in the emergence of cancer stem cells, such as the Hedgehog, Wnt, and Notch pathways, has important implications.

Because prostate cancer progression is partially affected by development of resistance of the cancer cells to apoptosis induced by anticancer drugs, the ability to sensitise apoptotic signalling pathways has important therapeutic implications.

Crosstalk between these two key inflammatory and developmental pathways has important biological implications, and provides a rationale for combination therapy in the treatment of patients with claudin-low breast cancer.

Consequently, our study demonstrates that vitamin D-VDR pathway has important roles in brain.