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We hypothesized that sorafenib cardiotoxicity is related to its deleterious effects on specific cardiac metabolic pathways given the critical roles of protein kinases in cardiac metabolism.
It is possible that a deficiency of SNX5 could result in perturbation of macropinosomes as well as general endosomal transport pathways, given the potential role of SNX5 also in retromer function (Wassmer et al., 2007).
The linear programming model (1 - 10) infers the pathways given the source, the target and the whole network G V,E,D,C,T), where V is the set of proteins and DNAs, E is the set of protein-protein interactions and protein-DNA interactions, D defines the dissipation indix on each edge, C defines the capacity of each edge, and T defines the orientations of the interactions.
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Consequently, experimental results indicated that these combined pathways gave the most efficient conversion of glucose to succinate with the highest yield using only 1.25 moles of NADH per mole of succinate in contrast to the sole fermentative pathway, which uses 2 moles of NADH per mole of succinate.
Pathways: Pathways gives the list of pathways in which genes enter.
It is also not what is currently limiting the use of the new pathway given the number of biologics for which the 12 exclusivity has already long expired.
Notably, some C18 is obtained (with 5%% selectivity), indicating that hydrodeoxygenation occurs in parallel with decarbonylation/decarboxylation, although together the latter processes constitute the major pathway given the higher selectivity of C17 observed.
Laser ablation of telomeres may also act through this pathway, given the common endpoint of cleavage furrow regression [28].
22 SSB repair (SSBR) is most accurately considered a BER-related pathway, given the similarity of substrates and shared protein members.
This method seeks to assess the activation probability of every circuit, representing a canonical functionality within the pathway, given the status of the sample (e.g., disease, control, etc).
This pathway and the concomitant genes in E. coli probably represent the most highly evolved Kdo2-lipid A biosynthetic pathway given the highly adapted association of E. coli with vertebrate enteric habitats, which depends heavily on the structure of LPS.
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