Sentence examples for pathways function to from inspiring English sources

The existence of selective groups of up- and downregulated genes in these scenarios supports the supposition that distinct molecular pathways function to signal self-renewal in different contexts.

In addition, both Hedgehog and Notch signalling pathways function to inhibit MSC differentiation towards the osteoblastic lineage.

A series of recent studies have significantly advanced our understanding of how the multiple and redundant eukaryotic pathways function to facilitate this fundamental process [ 33– 433.

UPR signalling pathways function to reduce the rate of protein synthesis and up-regulate the expression of chaperones and ERAD factors, thereby reducing levels of misfolded proteins in the ER and restoring homoeostasis.

The proper development of metazoans is governed by changes in the transcriptional profile of various tissues and cell types over time, and several evolutionarily conserved signaling pathways function to stimulate the transcriptional changes necessary for changes in cell fate and behavior during development.

Negative feedback on TOR pathway function to restrict the expression of FLO11 under nitrogen starved condition and also with re-addition of nitrogen to starved cells.

ICOS ligand and the ICOS pathway function to trigger effector T cell responses and generate follicular helper T cells [ 52].

Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.

Therefore increase and/or activation of aldolase appear to be implicated in the plant growth mainly through promotion of the glycolytic pathway function to synthesize ATP [ 58].

Analysis of the sensitivity of the IT pathway function to the kinetic properties of each of its components may provide insight into the distribution of negative and positive selection along the pathway.

One prediction from coupling between enzymes in a pathway is that when a pathway is under negative selection (or other types of selection), that the selective pressure on amino acid change in an individual protein will relate to the sensitivity of pathway function to perturbation of each individual enzyme based upon amino acid changes.