Profiling the expression of numerous gene sets in normal versus pathological states can provide critical clues to intracellular signaling pathway function, as well as to identities of genes that play important roles in carcinogenesis.
Apart from its function in the coagulation system, TF attracted considerable attention as a potential mediator in intracellular signaling of established inflammatory pathways, functioning as an intermediate for factor VIIa-induced activation of mitogen-activated protein kinases and calcium signaling.
Therefore, both the canonical and the non-canonical NF-κB pathway function as tumour suppressors in Myc-transformed murine lymphoma and most likely human Burkitt lymphoma.
Other gene modules comprise genes that augment a specific pathway function, as exemplified by aflR/aflS, the pathway-specific transcription activator and enhancer [ 59], and aflX/aflY, the genes required for the conversion of versicolorin A to demethylsterigmatocystin [ 60].
In conclusion, the BD-L metagene may provide a measure of BRCA1 pathway function as opposed to indicating BRCA1 mutational status, direct expression levels, or response to an acute stimulus.
This pathway functions as a complex, mutually coherent system of functionally interacting molecules.
In addition, we discovered that the BAF60c-mediated glucose sensing pathway functions as an extra-pancreatic target of sulfonylurea drugs to exert their full glucose lowering effects.
The succinylase branch of the lysine production pathway functions as the bridging reaction to convert succinyl-CoA to succinate in this aerobic bacterium.
Thirdly, although primary IgG1 response was not detected in wild-type mice, remarkable IgG1 response was induced in TLR9-deficient mice, suggesting that TLR9 pathway functions as regulatory, but not a simple augmenting signaling cascade, and furthermore, the enhanced IgG1 response was not due to adjuvant effect of single-stranded DNA derived from M13 phage.
