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Signalling pathways formed a relatively discrete cluster connected to the centre of the network.
As shown in Additional file 2: Figure S7, vitamin- and amino acid-related pathways formed a linked network.
For de novo Membership, Notch and Tor pathways formed a separate concept and for de novo GOSlim, Base excision repair and Mismatch Repair formed a separate concept.
Overall, most inhibitors of oncogenic kinase pathways formed a unique cluster in the hierarchical clustering analysis as well as in the principal component analysis.
Note: n/a - indicates all pathways formed a single cluster As expected in the fine-tuning of the DC methods the maximal number of pathways in pathway concepts decreases as the number of pathways increases.
Of note, inhibitors of oncogenic kinase pathways formed a large unique cluster, showing that these agents affect a shared molecular pathway distinct from classical antitumor agents and other classes of agents.
Similar(53)
Just like the way that many food chains constitute a food web, multiple signaling pathways form a signaling network in macrophages.
Multiple signaling pathways form a complicated network to modulate the hepatic apoptosis.
Height is clearly associated with most pathways, forming a major hub in the PHPN.
The insulin and TOR pathways form a signaling network that integrates information about nutrient availability and an intrinsic developmental program.
With the exception of two pathways (linoleic acid metabolism and selenoamino acid metabolism), all universal pathways form a connected component of the network.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com