Nursing simulation fellowships aimed at developing expert simulation knowledge and leadership skills can be a viable pathway for developing simulation leaders to fill these roles.
To assess the impact of the number of genes within a GS on the power and type I error rate, we also varied the size of the GS by removing 10 genes from the pathway for some simulations, so that the GS size was 17 or 27.
For simulation of coupled pathways competition, one random number (R) was generated to sample both TD and TS.
For simulation of independent pathways competition, two independent random numbers (uniformly distributed between 0 and 1), one corresponding to death (RD) and the other corresponding to slippage (RS), were generated using the Random function in MATLAB.
In this paper we describe STEPS, STochastic Engine for Pathway Simulation, which was designed to give modelers an efficient implementation with a sophisticated user interface.
For simulation of independent pathway competition, mitotic death and slippage events were randomly and independently generated from their respective cumulative distributions. 100 single-cell events were generated per simulation.
PSFC may be used for the purpose of assessment of pathway activity deregulations in different conditions, for simulation studies on network dynamics, etc.
For simulation of kinetically correlated pathway competition, mitotic death and slippage events were chosen in a correlated fashion.
The tools most commonly used for simulation checks are COmplex PAthway SImulator, 15 the SBMLodeSolver, 16 SBMLSimulator, 17 or the facilities provided by the Systems Biology Workbench.
As the model reconstructed in Pathway Tools was not formulated or formatted for simulation purposes, the model was restructured into RAVEN Toolbox format.
