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There exists several different pathways for loading antigenic peptides onto MHC class I molecules, either based on the endogenous cytosolic MHC I pathway or on cross-presentation.
Transport of N during seasonal N cycling is a particularly weak link, since the physical pathways for loading and unloading of amino N to and from the phloem are poorly understood.
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In many professional APCs, endogenous antigens are transferred to the endosomal/lysosomal pathway for loading onto HLA class II molecules [ 12].
CellDesigner can export pathways into files for loading into other software such as Cytoscape (Shannon et al., 2003), where SBGN is an ancilliary feature to network analysis functions.
The endosomal route is considered to be the default pathway for the loading of class II MHC molecules.
Here we report the use of the evolutionarily conserved late-domain (L-domain) pathway as a mechanism for loading exogenous proteins into exosomes.
The rupture force was strongly dependent on the direction of applied force, indicating the existence of distinct unbinding pathways for the two force-loading modes.
The main steps in mechanotransduction for connective tissues have been essentially unravelled for bone, but there remain unknown elements in the load-induced signalling pathways for muscle, 8 9 tendon 10– 12 and articular cartilage.
Actin was used for loading control.
Ask about parking for loading and unloading.
Furthermore, there is evidence that integrins serve as receptors for both mechanical loading and matrix fragments implicating overlapping pathways for these signals [ 15, 19, 60, 61].
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